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Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo

โœ Scribed by L. Chi; Y. Ke; C. Luo; D. Gozal; R. Liu


Book ID
116788003
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
687 KB
Volume
144
Category
Article
ISSN
0306-4522

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Apoptosis plays a major role in motor neuron survival during developmental cell death, after axotomy, and in motor neuron diseases. Bax is the first member of the bcl-2 family shown to promote apoptosis. In the present study, we used the bax-deficient mouse model to determine the role of bax in moto