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Depletion of Mutant p53 and Cytotoxicity of Histone Deacetylase Inhibitors

✍ Scribed by Blagosklonny, M. V.; Trostel, S.; Kayastha, G.; Demidenko, Z. N.; Vassilev, L. T.; Romanova, L. Y.; Bates, S.; Fojo, T.

Book ID: 121677149
Publisher: American Association for Cancer Research
Year: 2005
Tongue: English
Weight: 528 KB
Volume: 65
Category: Article
ISSN: 0008-5472
DOI: 10.1158/0008-5472.CAN-04-3433

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## Abstract Histone deacetylases inhibitors (HDIs) induce growth arrest and apoptosis in a variety of human cancer cells. Sodium butyrate (NaB), a histone deacetylase inhibitor, has been shown to cause a G~1~ cell cycle arrest by inducing p21^WAF1/CIP1^ in a __p53__‐independent manner. In this repo