Depletion of high-energy phosphates in the central nervous system of patients with systemic lupus erythematosus, as determined by phosphorus-31 nuclear magnetic resonance spectroscopy
✍ Scribed by Richard H. Griffey; Mark S. Brown; Arthur D. Bankhurst; Randy R. Sibbitt; Wilmer L. Sibbitt JR.
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 630 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
Systemic lupus erythematosus (SLE) can produce profound disturbances in the central nervous system, characterized by encephalopathy, focal neurologic deficits, cerebral infarction, psychosis, and seizures. We used "P nuclear magnetic resonance (NMR) spectroscopy to determine the in vivo levels of high-energy phosphates in the central nervous system of 10 patients with SLE and 10 age-matched normal controls. "P NMR spectroscopy was performed on a 1.5-Tala unit equipped with a dual-tuned IH-"P surface coil and a software-directed DRESS (depth resolved surface coil spectroscopy) pulse sequence. This procedure detected ADP, ATP, sugar phosphates, phosphocreatine (PCr), inorganic phosphate, phosphomonoesters, and phosphodiesters in the brain tissue of all study subjects. Levels of ATP in the deep white matter of 10 SLE
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From the Center for Non-lnvasive Diagnosis. the Depart-