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Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies

✍ Scribed by Hiroshige Fujishiro; Hiroyuki Umegaki; Daisuke Isojima; Hiroyasu Akatsu; Akihisa Iguchi; Kenji Kosaka

Book ID
106073187
Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
319 KB
Volume
111
Category
Article
ISSN
0001-6322

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Impaired and spared cholinergic function
Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin
✍ Qing Chang; Paul E. Gold πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 254 KB

## Abstract To lesion the cholinergic input to the hippocampus, rats received injections of 192 IgG‐saporin into the medial septum/vertical limb of the diagonal band (MS/VDB). The lesions produced near‐total loss of choline acetyltransferase (ChAT)‐positive neurons in the MS/VDB. The loss was accom