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Depigmentation and inhibition of cell growth of B-16 melanoma cells by compounds isolated fromPaeonia suffruticosacallus

✍ Scribed by Yukihiro Shoyama; Yoichi Yamada; Itsuo Nishioka; Hiroshi Matsunaka

Publisher: Springer
Year: 1990
Tongue: English
Weight: 282 KB
Volume: 8
Category: Article
ISSN: 0721-7714
DOI: 10.1007/bf00272100

No coin nor oath required. For personal study only.

✦ Synopsis

The anther segments of Paeonia suffruticosa Andrews were cultured for callus formation on MS medium supplemented with 2,4-D and BAP(each 1 mg/l) in the dark at 25°C for six weeks. Gallic acid, methyl gallate, ethyl gallate and 1,2,3,4,6-penta-O-galloyl-β-D-glucose were isolated from the ethanol extract of callus, and paeoniflorin was identified. A dose of 5 μg/ml pentagalloyl glucose resulted in depigmentation of B-16 melanoma cells without inhibition of cell propagation.

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