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Deoxyoligonucleotides containing 2′,5′ acetal linkages: Synthesis and hybridization properties

✍ Scribed by Jeffrey S. Pudlo; Xiaodong Cao; S. Swaminathan; Mark D. Matteucci

Book ID
108380219
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
326 KB
Volume
35
Category
Article
ISSN
0040-4039

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The synthesis and binding properties of
The synthesis and binding properties of oligonucleotide analogs containing diastereomerically pure conformationally restricted acetal linkages
✍ Jianying Wang; Mark D. Matteucci 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 182 KB

The synthesis of 5,6-bicyclic thymine:thymine nucleoside containing a conformationally restricted dioxane acetal has been achieved from 2'-O-allyl 5-methyl uridine. The two diastereomers were separated and incorporated in a single position within an oligonucleotide (ON) sequence. The binding propert