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Denileukin diftitox (ONTAK) as targeted therapy against steroid refractory graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT)

✍ Scribed by V.T. Ho; E. Hochberg; D. Zahrieh; C. Cutler; S. Steckel; S.J. Lee; E.P. Alyea; J. Ritz; R.J. Soiffer; J.H. Antin


Book ID
116277552
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
47 KB
Volume
10
Category
Article
ISSN
1083-8791

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## Abstract Etanercept is a recombinant human soluble tumor necrosis factor (TNF‐α) receptor fusion protein that inhibits TNF‐α, a major mediator in the pathogenesis of graft‐versus‐host disease (GVHD). The purpose of our study was to evaluate the safety and efficacy of etanercept therapy in 21 pat