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Dengue epidemic in the State of Rio Grande do Norte, Brazil, in 1997

✍ Scribed by Rivaldo V. Cunha; Hermann G. Schatzmayr; Marize P. Miagostovich; Ana M.A. Barbosa; Francisca G. Paiva; Regina M.O. Miranda; Carlos C.F. Ramos; Janice C.O. Coelho; F.B. dos Santos; Rita M.R. Nogueira

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 416 KB
Volume: 93
Category: Article
ISSN: 0035-9203
DOI: 10.1016/s0035-9203(99)90008-1

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✦ Synopsis

During 1997 a large dengue epidemic occurred in Rio Grande do Norte, a State in north-east Brazil. The cocirculation of dengue virus type 1 and dengue virus type 2 was demonstrated by virus isolation in Aedes albopictus clone C6/36 cell-line and by reverse transcriptase-polymerase chain reaction (RT-PCR). IgM capture enzyme-linked immunosorbent assay confirmed 52.3% of the 8105 studied cases and dengue antigen was demonstrated by immunohistochemical reaction on hepatocytes from 2 out of 5 fatal cases studied. Individual risk factors for development of dengue haemorrhagic fever/dengue shock syndrome, such as hypertension, diabetes mellitus and bronchial asthma, are discussed.

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