Dendritic cell–tumor cell hybrid vaccination for metastatic cancer
✍ Scribed by Jose Alexandre M. Barbuto; Luis F. C. Ensina; Andreia R. Neves; Patrícia C. Bergami-Santos; Katia R. M. Leite; Ricardo Marques; Frederico Costa; Siderleny C. Martins; Luiz H. Camara-Lopes; Antonio C. Buzaid
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 285 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0340-7004
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Early clinical trials, in which over 1000 cancer patients received dendritic cell (DC) vaccines, tested different vaccine preparations, but they did not always induce sufficient acquired immunity or meet the expected level of tumor regressions. Current studies aim to improve the DC vaccine approach
Hybrid cell vaccination is a new cancer immune therapy approach that aims at recruiting T cell help for the induction of tumour specific cytolytic immunity. The vaccines are generated by fusion of the patients' tumour cells with allogeneic MHC class II bearing cells to combine the tumour's antigenic