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Dendritic cells of the mouse recognized by two monoclonal antibodies

✍ Scribed by Matthijs Breel; Reina E. Mebius; Georg Kraal

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 707 KB
Volume: 17
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830171105

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✦ Synopsis

A new monoclonal antibody, MIDC-8, is described which shows a comparable tissue distribution as the recently described NLDC-145 antibody. It recognizes interdigitating cells, veiled cells and Langerhans cells in lymphoid organs and the skin of the mouse. In contrast to NLDC-145 it recognizes a cytoplasmic component of these cell types. Its distribution is more restricted to the T cell-dependent areas than NLDC-145. Isolation of dendritic cells from lymph nodes, spleen and thymus revealed that both antibodies react with the in vitro isolated dendritic cells. The results show that these antibodies can be used to study dendritic cells in vitro and emphasize the relationship between the in vivo interdigitating cells of the T cell areas and the in vitro isolated dendritic cells.

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