Dendritic Cells and Virus Infection

✍ Scribed by R. M. Steinman, A. Granelli-Piperno, M. Pope, C. Trumpfheller, R. Ignatius, G. Arrode (auth.), Prof. Dr. Alexander Steinkasserer (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2003
• Tongue: English
• Leaves: 302
• Series: Current Topics in Microbiology and Immunology 276
• Edition: 1
• Category: Library

✦ Synopsis

Dendritic cells (DC) are vital to induce potent anti-viral immune responses. However, viruses have developed a large number of different escape mechanisms in order to overcome the host immune system. A prime target in this respect are DC, since they are the only antigen presenting cell able to induce also naive T cells. In the present CTMI-volume the interaction between several viruses, including HIV-1, SIV, EBV, measles virus, LCMV and HSV-1, with DC will be described and discussed. It will become clear to the reader that DC often play a dual role during viral infections. On the one hand they are able to mount potent antiviral immune responses, and the other hand several viruses, including HIV-1, use DC as a vector to be transferred from the periphery to the lymph nodes were they infect their prime target cells. In the second part of this volume several DC specific immune intervention strategies will be presented. This includes topics such as DC vaccination strategies in immunotherapy, viral vectors for the genetic modification of DC and cross presentation of virus infected cells by DC.

✦ Table of Contents

Front Matter....Pages I-X
The Interaction of Immunodeficiency Viruses with Dendritic Cells....Pages 1-30
DC-SIGN: A Novel HIV Receptor on DCs That Mediates HIV-1 Transmission....Pages 31-54
Contrasting Roles of Dendritic Cells and B Cells in the Immune Control of Epstein-Barr Virus....Pages 55-76
Dendritic Cells and Measles Virus Infection....Pages 77-101
Measles Virus and Dendritic Cell Functions: How Specific Response Cohabits with Immunosuppression....Pages 103-123
Infection of Dendritic Cells by Lymphocytic Choriomeningitis Virus....Pages 125-144
The Interaction Between Dendritic Cells and Herpes Simplex Virus-1....Pages 145-161
Dendritic Cell-Based Immunotherapy....Pages 163-197
Dendritic Cell Vaccination and Viral Infection — Animal Models....Pages 199-214
Interplay Between Human Papillomaviruses and Dendritic Cells....Pages 215-240
Viral Vectors for Dendritic Cell-Based Immunotherapy....Pages 241-259
Cross-Presentation of Cell-Associated Antigens by Dendritic Cells....Pages 261-275
Dendritic Cells and HCMV Cross-Presentation....Pages 277-294
Back Matter....Pages 295-298

✦ Subjects

Virology