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Dendritic cell vaccine with mRNA targeted to the proteasome by polyubiquitination

✍ Scribed by Akihiro Hosoi; Yayoi Takeda; Kazuko Sakuta; Satoshi Ueha; Makoto Kurachi; Kiminori Kimura; Ryuji Maekawa; Kazuhiro Kakimi

Book ID
116296704
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
583 KB
Volume
371
Category
Article
ISSN
0006-291X

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## Abstract Dendritic cell (DC)‐based vaccines have become important in immunotherapeutics as a measure for generating antitumor immune responses. We have previously demonstrated that linkage of the antigen gene to a lysosomal targeting signal, a sorting signal of the lysosome‐associated membrane p