Blocking CD40 – CD154 and CD80/CD86 – CD
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Stefaan W. Van Gool; Jan Vermeiren; Khadija Rafiq; Katrien Lorré; Mark de Boer;
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Article
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1999
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John Wiley and Sons
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English
⚖ 139 KB
Although CD28 triggering provides an important co-stimulatory signal to T cells, blocking the CD80/CD86 -CD28 interaction with CTLA-4lg fusion protein is not sufficient for tolerance induction in vivo or in vitro. According to more recent data, interruption of the CD40 -CD154 interaction might compl