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Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions

✍ Scribed by Amy J. Miga; Sally R. Masters; Brigit G. Durell; Mercedes Gonzalez; Marc K. Jenkins; Charles Maliszewski; Hitoshi Kikutani; William F. Wade; Randolph J. Noelle


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
124 KB
Volume
31
Category
Article
ISSN
0014-2980

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Although CD28 triggering provides an important co-stimulatory signal to T cells, blocking the CD80/CD86 -CD28 interaction with CTLA-4lg fusion protein is not sufficient for tolerance induction in vivo or in vitro. According to more recent data, interruption of the CD40 -CD154 interaction might compl