The authors report five pediatric patients with acute lymphoblastic leukemia (ALL) in whom symptomatic aseptic osteonecrosis developed on therapy. All patients had been on treatment with a modified BFM protocol and developed osteonecrosis in the maintenance phase of the protocol. The avascular necro
Dendritic cell deficiencies in pediatric acute lymphoblastic leukemia patients
β Scribed by Maecker, B; Mougiakakos, D; Zimmermann, M; Behrens, M; Hollander, S; Schrauder, A; Schrappe, M; Welte, K; Klein, C
- Book ID
- 110056667
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 125 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0887-6924
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Endocrine complications of therapy for acute lymphoblastic leukemia (ALL) are common and are potentially debilitating both during and after therapy. Growth velocity slows during therapy for ALL, especially during the first year; however, children who do not receive cranial irradiation usually reach
## Abstract ## BACKGROUND. Dexamethasone improves the cure rate of childhood acute lymphoblastic leukemia (ALL) but causes physical and behavioral adverse events. The objective of the current study was to determine the effect of dexamethasone exposure on sleep and fatigue in pediatric patients wit