Dendritic Carrier Based on PEG: Design and Degradation of Acid-sensitive Dendrimer-like Poly(ethylene oxide)s

✍ Scribed by Xiaoshuang Feng; Elliot L. Chaikof; Christelle Absalon; Carlos Drummond; Daniel Taton; Yves Gnanou

• Book ID: 102943151
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 738 KB
• Volume: 32
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.201100459

✦ Synopsis

Abstract

Degradable dendrimer‐like PEOs were designed using an original ABC‐type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer‐like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 kg · mol^−1^ was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (≈2 kg · mol^−1^), as monitored by ^1^H NMR, SEC, and MALDI‐TOF mass spectrometry as well as by AFM.magnified image