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Denaturing Gradient Gel Electrophoresis Analysis of the Tissue Nonspecific Alkaline Phosphatase Isoenzyme Gene in Hypophosphatasia

✍ Scribed by Steven Mumm; Jonathan Jones; Patrick Finnegan; Paula S. Henthorn; Michelle N. Podgornik; Michael P. Whyte


Book ID
115639953
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
355 KB
Volume
75
Category
Article
ISSN
1096-7192

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Hypophosphatasia is a rare inherited disorder characterized by defective bone mineralization and deficiency of serum and tissue liver/bone/kidney tissue alkaline phosphatase (L/B/K ALP) activity. We report here the characterization of tissue-nonspecific alkaline phosphatase (TNSALP) gene mutations i