✦ LIBER ✦

Demonstration ofrasandp53Gene Mutations in Carcinomas in the Forestomach and Intestine and Soft Tissue Sarcomas Induced byN-Methyl-N-nitrosourea in the Rat

✍ Scribed by Matsumoto, Kazuyuki ;Iwase, Teruhiko ;Hirono, Iwao ;Nishida, Yoshihisa ;Iwahori, Yoshio ;Hori, Takaaki ;Asamoto, Makoto ;Takasuka, Nobuo ;Kim, Dae Joong ;Ushijima, Toshikazu ;Nagao, Minako ;Tsuda, Hiroyuki

Book ID: 108581388
Publisher: Wiley (Blackwell Publishing)
Year: 1997
Tongue: English
Weight: 448 KB
Volume: 88
Category: Article
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1997.tb00357.x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Alterations in the Ha-ras-1 and the p53

Alterations in the Ha-ras-1 and the p53 pathway genes in the progression of N-methyl-N-nitrosourea–induced rat mammary tumors

✍ Katherine E. McKenzie; Barbara A. Armstrong; Ying Chen; Mahalakshmi Nagarajan; C 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB 👁 2 views

Well-differentiated mammary carcinomas carrying mutated Ha-ras-1 oncogenes arise frequently in pubescent rats exposed to the direct-acting methylating agent N-methyl-N-nitrosourea (MNU). When these tumors are serially transplanted, they acquire more aggressive phenotypes. To determine the genetic al

Application of the restriction site muta

Application of the restriction site mutation technique to N-methyl-N-nitrosourea-induced mutations in the rat

✍ Sinan Suzen; Gareth J. S. Jenkins; James M. Parry 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB 👁 1 views

The restriction site mutation (RSM) assay was developed in this laboratory for the detection of point mutations that occur within restriction endonuclease recognition sequences in the genomic DNA of the rat. Mutations were detected and identified in a number of tissues from N-methyl-N-nitrosourea (M

Frequent activation of the Ki-ras oncoge

Frequent activation of the Ki-ras oncogene at codon 12 in N-methyl-N-nitrosourea-induced rat prostate adenocarcinomas and neurogenic sarcomas

✍ Saraswati Sukumar; Barbara Armstrong; Joost P. Bruyntjes; Irwin Leav; Maarten C. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 892 KB

Rat neoplasms induced by methylating carcinogens frequently contain ras genes activated by a single point mutation. Rat prostatic tumors induced by a combination of a single injection of N-methyl-N-nitrosourea (MNU) and long-term treatment with testosterone were examined for the presence of such act