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Demonstration of Robust Host Cell Protein Clearance in Biopharmaceutical Downstream Processes

✍ Scribed by Abhinav A. Shukla; Canping Jiang; Junfen Ma; Michael Rubacha; Lisa Flansburg; Steven S. Lee

Book ID: 109387765
Publisher: American Institute of Chemical Engineers
Year: 2008
Tongue: English
Weight: 86 KB
Volume: 24
Category: Article
ISSN: 8756-7938
DOI: 10.1021/bp070396j

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## Abstract Host cell proteins (HCPs) constitute a major group of impurities for biologic drugs produced using cell culture technology. HCPs are required to be closely monitored and adequately removed in the downstream process. However, HCPs are a complex mixture of proteins with significantly dive