𝔖 Bobbio Scriptorium
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Demonstration of antigens related to colonic cancer in the human digestive system

✍ Scribed by F. Martin; M. S. Martin

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
670 KB
Volume
6
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Heteroimmunization of rabbits with saline or perchloric extracts of colonic cancers permits the detection of two cancer‐related antigens. These antigens may be demonstrated, by direct precipitin reaction, in saline extracts of colonic or rectal adenocarcinomata, of some gastric cancers, and of foetal gut, but not in saline extracts of the non‐cancerous adult digestive system. However, precipitin‐inhibition reaction shows these antigens in perchloric extracts of non‐cancerous colonic mucosa but their concentration is much weaker than in intestinal tumours. Detection of a small amount of these antigens in non‐cancerous colonic mucosa implies that they are cancer‐related, but not cancer‐specific. Identity of one of the antigens with Gold's carcinoembryonic antigen is discussed.

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