Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

✍ Scribed by Martinez, Gary V.; Navath, Suryakiran; Sewda, Kamini; Rao, Venkataramanarao; Foroutan, Parastou; Alleti, Ramesh; Moberg, Valerie E.; Ahad, Ali M.; Coppola, Domenico; Lloyd, Mark C.; Gillies, Robert J.; Morse, David L.; Mash, Eugene A.

• Book ID: 122581566
• Publisher: Elsevier Science
• Year: 2013
• Tongue: English
• Weight: 476 KB
• Volume: 23
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2013.02.008

✦ Synopsis

A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd–DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T
1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.