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Demonstration of a Specific [3H]INS(1,4,5)P3 Binding Site in Rat Heart Sarcoplasmic Reticulum

✍ Scribed by B. Huisamen; R. Mouton; L.H. Opie; A. Lochner


Book ID
115631921
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
477 KB
Volume
26
Category
Article
ISSN
0022-2828

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## Abstract PRIP‐1 was isolated as a novel inositol 1,4,5‐trisphosphate [Ins(1,4,5)P~3~] binding protein with a domain organization similar to phospholipase C‐δ1 (PLC‐δ1) but lacking the enzymatic activity. Further studies revealed that the pleckstrin homology (PH) domain of PRIP‐1 is the region re