Demographic heterogeneity explains age-specific patterns of genetic variance in mortality rates

Patterns of Age-specific Means and Genet

Patterns of Age-specific Means and Genetic Variances of Mortality Rates Predicted by the Mutation-Accumulation Theory of Ageing

✍ BRIAN CHARLESWORTH 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 520 KB

A general quantitative genetic model of mutations with age-speci"c deleterious e!ects is developed. It is shown that, for the simplest case of a species with age-independent reproductive rates and extrinsic adult mortality rates, and no pleiotropic e!ects of age-speci"c mutations, exponential increa