𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Delivery of therapeutic proteins

✍ Scribed by Dipak S. Pisal; Matthew P. Kosloski; Sathy V. Balu-Iyer

Book ID
102399644
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
298 KB
Volume
99
Category
Article
ISSN
0022-3549

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✦ Synopsis

The safety and efficacy of protein therapeutics are limited by three interrelated pharmaceutical issues, in vitro and in vivo instability, immunogenicity and shorter half-lives. Novel drug modifications for overcoming these issues are under investigation and include covalent attachment of poly(ethylene glycol) (PEG), polysialic acid, or glycolic acid, as well as developing new formulations containing nanoparticulate or colloidal systems (e.g., liposomes, polymeric microspheres, polymeric nanoparticles). Such strategies have the potential to develop as next generation protein therapeutics. This review includes a general discussion on these delivery approaches.

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Biological drugs are usually complex proteins and cannot be orally delivered due to problems related to degradation in the acidic and protease-rich environment of the gastrointestinal (GI) tract. The high molecular weight of these drugs often results in poor absorption into the periphery when admini