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Delivery of DNA and siRNA by novel gemini-like amphiphilic peptides

✍ Scribed by Mark Damen; Jamil Aarbiou; Stijn F.M. van Dongen; Ruvalic M. Buijs-Offerman; Patricia P. Spijkers; Maaike van den Heuvel; Kristina Kvashnina; Roeland J.M. Nolte; Bob J. Scholte; Martin C. Feiters

Book ID
113693312
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
538 KB
Volume
145
Category
Article
ISSN
0168-3659

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Amphiphilic peptides with arginines and
Amphiphilic peptides with arginines and valines for the delivery of plasmid DNA
✍ Dong-Wook Ryu; Hyun Ah Kim; Hojung Song; Soonhag Kim; Minhyung Lee πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 795 KB

## Abstract A non‐toxic and efficient gene carrier is one requirement for clinical gene therapy. In this study, amphiphilic peptides composed of arginines and valines were synthesized and characterized as plasmid DNA (pDNA) carriers. The peptides have a cationic region containing 1–4 arginines and