Delivery of Anticancer Drugs Using Polymeric Micelles Stabilized by Hydrogen-Bonding Urea Groups
✍ Scribed by Jeremy P. K. Tan; Sung Ho Kim; Fredrik Nederberg; Kazuki Fukushima; Daniel J. Coady; Alshakim Nelson; Yi Yan Yang; James L. Hedrick
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 455 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1022-1336
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✦ Synopsis
Abstract
Polymeric micelles comprising a hydrogen‐bonding core were formed from block copolymers with pendant urea groups and explored as drug delivery vehicles. The amphiphilic block copolymers were synthesized by organocatalytic ring opening polymerization (ROP) of urea‐functionalized cyclic carbonates from a poly(ethylene glycol) macroinitiator. The urea functionality was incorporated because its ability to increase the hydrophobic core's affinity toward polar organic compounds through intermolecular hydrogen bonding. Doxorubicin (DOX), a lipophilic anticancer drug with hydrogen‐bonding functionalities, was systematically incorporated into the micelle's hydrophobic interior via hydrogen bonding to the functionalized monomers. Micelles employing urea groups were found to more efficiently interact with DOX thus allowing increased drug loading capacity while maintaining a desirable micellular size. More importantly, while DOX‐loaded micelles were shown to kill HepG2 human liver carcinoma cell lines efficiently, all of the polymers were non‐cytotoxic.
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