Delivery of Active DACH-Pt Anticancer Species by Biodegradable Amphiphilic Polymers Using Thiol-Ene Radical Addition
✍ Scribed by Haihua Xiao; Dongfang Zhou; Shi Liu; Ruogu Qi; Yonghui Zheng; Yubin Huang; Xiabin Jing
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 363 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
A biodegradable and amphiphilic copolymer, mPEG__‐b‐P(LA‐co‐MAC/TMA) that contains pendant 1,2‐bidentate carboxyl groups is synthesized by thiol‐ene radical addition and is further used to chelate with the active anticancer species (DACH‐Pt) of oxaliplatin to form an mPEG‐b‐P(LA‐co‐__MAC/TMA‐Pt‐DACH) complex. The polymer platinum complex can self‐assemble into micelles. In vitro studies show that the DACH‐Pt micelles display enhanced or comparable cytotoxicity against SKOV‐3 and MCF‐7 cancer cells, while they show reduced toxicity to HeLa cells compared with oxaliplatin.magnified image