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Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood

✍ Scribed by John I. Gallin; Thomas L. Leto; Daniel Rotrosen; Cheung H. Kwong; Harry L. Malech

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
547 KB
Volume
4
Category
Article
ISSN
0952-7915

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✦ Synopsis

The phagocyte NADPH oxidase is a complex system consisting of membrane and cytosolic components that must assemble at the membrane for proper activation. Studies of patients with chronic granulomatous diseases of childhood have enabled the molecular characterization of these components, which has led to studies defining their interaction during NADPH complex assembly. Understanding NADPH oxidase assembly provides an opportunity to develop therapeutics for the regulation of this important reaction of inflammation.

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## For the Immunogenetics Special Issue Chronic granulomatous disease (CGD) is an inherited immunodeficiency caused by defects in any of four genes encoding components of the leukocyte nicotinamide dinucleotide phosphate, reduced (NADPH) oxidase. One of these is the autosomal neutrophil cytosolic