Acid-base titrations at 37ยฐC determined the PK. values in water and saline of twelve synthesized polypentapeptides, polycfv(GVGIP),fn(GKGIP) ), where&+&= 1 with& ranging from 1 to 0.06 and where K is the lysine (NH: /NH,) residue. In water the p& was 9.60 nearfx=0.9 decreasing to 9.20 at&= 1 and to
โฆ LIBER โฆ
Delineation of electrostatic- and hydrophobic-induced pKa shifts in polypentapeptides: the glutamic acid residue
โ Scribed by Urry, D. W.; Peng, S.; Parker, T.
- Book ID
- 126004518
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 235 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0002-7863
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Whenever hydrogen bonding is involved in molecular recognition, the possibility of a proton transfer from the donor to the acceptor arises. In most cases the pK a of the donor is far enough above the pK a of the conjugate acid of the acceptor for it to be clear that no proton transfer will occur. Ho