Several lines of evidence suggest that the progression of head-and-neck squamous-cell carcinoma (HNSCC) involves inactivation of at least one and possibly several tumorsuppressor genes on the long arm of chromosome 13. The fact that neither Rb1 nor BRCA2 appears to be inactivated in the majority of
Delineation and candidate gene mutation screening of the 18q22 minimal region of deletion in head and neck squamous cell carcinoma
✍ Scribed by Blons, Hélène; Laccourreye, Ollivier; Houllier, Anne-Marie; Carnot, Françoise; Brasnu, Daniel; Beaune, Philippe; Zucman-Rossi, Jessica; Laurent-Puig, Pierre
- Book ID
- 110066803
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 402 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci
## Abstract We report the finding of clonal structural chromosome abnormalities in short‐term cultures from 15 squamous cell carcinomas of the head and neck region. When the distribution of chromosomal breakpoints in these 15 tumors and in the 16 head and neck carcinomas previously described are as