Deletions on der(9) chromosome in adult Ph-positive acute lymphoblastic leukemia occur with a frequency similar to that observed in chronic myeloid leukemia

Translocation of BCR to chromosome 9: A

Translocation of BCR to chromosome 9: A new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia

✍ Dr. Anne Hagemeijer; Arjan Buijs; Elizabeth Smit; Bart Janssen; Geert-Jan Creeme 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 781 KB

## Abstract Leukemic cells from two patients with Philadelphia‐negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M‐BCR region and formation of __BCR‐ABL__ fusion mRNA with b2a2