We report on 2 girls with small de novo terminal deletions of the long arm of chromosome 2 and breakpoints within q37. Four cases with similar or more extensive deletions have been previously reported in full. Hypotonia and psychomotor retardation were the only manifestations common to all 6 cases.
Deletions of the short arm of chromosome 2 characterize a new cytogenetic subgroup of benign thyroid tumors
✍ Scribed by Gazanfer Belge; Sandra Bruckmann; Brita Thode; Sabine Bartnitzke; Jörn Bullerdiek
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 209 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Cytogenetic studies of thyroid hyperplasias and adenomas have shown that besides cases with an apparently normal karyotype different groups of cytogenetic abnormalities exin Herein we describe the cytogenetic analyses o f two benign thyroid tumors with deletions of the short arm of chromosome 2. A similar case has been described previously. Besides the previously well-established subgroups, alterations of chromosome 2 may thus characterize a new cytogenetic subgroup of benign thyroid tumors.
📜 SIMILAR VOLUMES
We report on a 4-month-old boy with a de novo interstitial deletion of the short arm of chromosome 3 (pter-->p21.2::p12-->qter) and clinical findings typical of proximal 3p deletion together with coloboma of iris, heart defect, choanal atresia, retardation of growth and development, genital hypoplas