DELETIONS OF MUSCLE MITOCHONDRIAL DNA
โ Scribed by Holt, I.J.; Cooper, J.M.; Morgan-Hughes, J.A.; Harding, A.E.
- Book ID
- 122583118
- Publisher
- The Lancet
- Year
- 1988
- Tongue
- English
- Weight
- 173 KB
- Volume
- 331
- Category
- Article
- ISSN
- 0140-6736
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๐ SIMILAR VOLUMES
Analysis of mitochondrial DNA (mtDNA) in muscle and blood from 72 patients with mitochondrial myopathy showed that 30 had major deletions of a variable proportion of muscle mtDNA. All of these 30 patients presented with progressive external ophthalmoplegia and limb weakness, and 8 had the additional
The abundance of mitochondrial DNA (mtDNA) deletions has been shown to increase with age in a number of species and may contribute to the aging process. Estimating the total mtDNA deletion load of an individual is essential in evaluating the potential physiological impact. In this study, we compared