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Deletions in the short arm of chromosome 8 are present in up to 90% of human colorectal cancer cell lines

✍ Scribed by Kai Van Der Bosch; Ilona Becker; Larisa Savelyeva; Silke Brüderlein; Peter Schlag; Manfred Schwab

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 478 KB
Volume: 5
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870050114

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✦ Synopsis

Cytogenetic analyses of human colon cancer cells have revealed non-random deletions in chromosome arm 8p, among other chromosomal changes. By using 8p-specific DNA probes we could identify allelic loss in 87% of colon cancer cell lines. Corresponding analyses in direct preparations of colon tumor tissues revealed a minimal value of 40% of allelic loss but were obstructed in many instances by contaminating normal tissue. These findings add to the number of non-random genetic alterations occurring during colon carcinogenesis. Genes Chrorn Concer 5 9 /-95 ( I 992). @ 1992 wiley-Liss, Inc.

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