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Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

✍ Scribed by McCarroll, Steven A; Huett, Alan; Kuballa, Petric; Chilewski, Shannon D; Landry, Aimee; Goyette, Philippe; Zody, Michael C; Hall, Jennifer L; Brant, Steven R; Cho, Judy H

Book ID
109914308
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
557 KB
Volume
40
Category
Article
ISSN
1061-4036

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Background: Recent genome-wide studies have implicated the autophagy genes ATG16L1 and IRGM in the pathogenesis of Crohn's disease (CD). We investigated whether these genes were associated with CD in Canadian children. ## Methods: A case-control study was carried out at 2 pediatric gastroenterolog