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Deletion of the ST2 proximal promoter disrupts fibroblast-specific expression but does not reduce the amount of soluble ST2 in circulation

✍ Scribed by Brian P. Lipsky; Dean Y. Toy; David A. Swart; Molly D. Smithgall; DirkE. Smith


Book ID
112082215
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
940 KB
Volume
42
Category
Article
ISSN
0014-2980

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The T1/ST2 gene encodes, as a result of differential splicing, a cell surface protein (transmembrane form of T1/ST2, ST2L) and a soluble, secreted, protein (ST2). Here, we show that transcripts for both ST2L and ST2 are present in activated human Th2 clones, but not in Th1 and T regulatory clones. T