Deletion analysis defines distinct functional domains for protein-protein and nucleic acid interactions in the ORF1 protein of mouse LINE-1

A Method for Defining Binding Sites Invo

A Method for Defining Binding Sites Involved in Protein–Protein Interactions: Analysis of the Binding of Plasminogen Activator Inhibitor 1 to the Somatomedin Domain of Vitronectin

✍ Gordon Royle; Gary Deng; Dietmar Seiffert; David J. Loskutoff 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 272 KB

Plasminogen activator inhibitor type-1 (PAI-1) is bound to vitronectin (VN) in plasma and in the extracellular matrix. We previously employed a domainswapping approach to show that the high-affinity binding site for PAI-1 in VN is contained within residues 12-30 in the amino-terminal somatomedin B (