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Deletion 7q22 in uterine leiomyoma: A cytogenetic review

โœ Scribed by Yavuz Y. Ozisik; Aurelia M. Meloni; Urvashi Surti; Avery A. Sandberg

Book ID
119105925
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
463 KB
Volume
71
Category
Article
ISSN
0165-4608

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This study further defines the region of consistent deletion of chromosome 7 in uterine leiomyomas. We have examined 74 leiomyomas for allelic loss of markers spanning the 7q22 region defined by markers D7S518 and D7S471. Forty tumors with cytogenetically defined 7q deletions, twenty-nine tumors wit

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Molecular cytogenetic characterization of del(7q) in two uterine leiomyoma-derived cell lines
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Uterine leiomyoma cytogenetically exhibits at least six chromosomally abnormal subgroups. The largest subgroup is characterized by deletions of the long arm of chromosome 7. Few molecular and fluorescence in situ hybridization data are available that have aimed at a better definition of the lesion.