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Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat

✍ Scribed by Valérie C Besson; Nicole Croci; Roger G Boulu; Michel Plotkine; Catherine Marchand-Verrecchia

Book ID
113999892
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
921 KB
Volume
989
Category
Article
ISSN
0006-8993

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## Abstract Recombinant tissue plasminogen activator (rt‐PA) treatment improves functional outcome after acute ischemic stroke, inducing reperfusion by its thrombolytic activity. Conversely, there is evidence that rt‐PA can mediate neuronal damage after ischemic brain injury in vivo. In addition to