Delayed wound healing in aged mice is associated with diminished mobilization of circulating angiogenic cells

Age-dependent impairment of HIF-1α expre

Age-dependent impairment of HIF-1α expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

✍ Lixin Liu; Guy P. Marti; Xiaofei Wei; Xianjie Zhang; Huafeng Zhang; Ye V. Liu; M 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 279 KB

## Abstract Wound healing is impaired in elderly patients with diabetes mellitus. We hypothesized that age‐dependent impairment of cutaneous wound healing in __db__/__db__ diabetic mice: (a) would correlate with reduced expression of the transcription factor hypoxia‐inducible factor 1α (HIF‐1α) as