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Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats

โœ Scribed by Yutaka Nishio; Masao Koda; Keiko Kitajo; Minoru Seto; Katsuhiko Hata; Junko Taniguchi; Hideshige Moriya; Masashi Fujitani; Takekazu Kubo; Toshihide Yamashita

Book ID
116458885
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
191 KB
Volume
200
Category
Article
ISSN
0014-4886

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Suppression of astroglial scar formation
Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine
โœ Dai-Shi Tian; Zhi-Yuan Yu; Min-Jie Xie; Bi-Tao Bu; Otto W. Witte; Wei Wang ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 614 KB

## Abstract It is well established that axons of the adult mammalian CNS are capable of regrowing only a limited amount after injury. Astrocytes are believed to play a crucial role in the failure to regenerate, producing multiple inhibitory proteoglycans, such as chondroitin sulphate proteoglycans