Delayed-release tablets using hydroxyethylcellulose as a gel-forming matrix
β Scribed by Mitsuyuki Matsuo; Kazuhiko Arimori; Chizuko Nakamura; Masahiro Nakano
- Book ID
- 113368615
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 712 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0378-5173
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The challenge of designing a delayed-release oral dosage form is significantly increased when the drug substance is poorly water soluble. This manuscript describes the design and characterization of a novel controlled-release film-coated tablet for the pH-triggered delayed and complete release of po
Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB