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Delayed HBsAg clearance in chronic hepatitis B viral infection

✍ Scribed by Karen L. Lindsay; Allan G. Redeker; Mary Ashcavai

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
473 KB
Volume
1
Category
Article
ISSN
0270-9139

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✦ Synopsis

Seven patients are described in whom HBsAg persisted for 13 to 98 months after acute viral hepatitis B and then became nondetectable. All patients subsequently developed anti-HBs. During the period of HBs-antigenemia, liver biopsies in five patients showed persistent viral hepatitis. Retrospectively, impending negativity of HBsAg was predictable in five patients by a decrease in HBsAg titer, and in four patients by persistent normalization of serum alanine aminotransferase. Although delayed clearance of HBsAg in patients with chronic hepatitis B virus infection is uncommon, it appears to be predictable.

A t least 90% (1-3) of adult patients with symptomatic acute viral hepatitis B (AVH-B) resolves the infection

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