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Delayed dermal hypersensitivity in Rhesus monkeys (Macaca mulatta) immunized againstPlasmodium knowlesi

✍ Scribed by Edelberto J. Cabrera; Clarence A. Speer; Robert H. Schenkel; Mary L. Barr; Paul H. Silverman

Book ID: 104751667
Publisher: Springer-Verlag
Year: 1976
Tongue: English
Weight: 747 KB
Volume: 50
Category: Article
ISSN: 1432-1955
DOI: 10.1007/bf00389929

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✦ Synopsis

Eighteen Rhesus monkeys were immunized with a fresh or lyophilized antigen preparation obtained from erythrocytes infected with Plasmodium knowlesi. Sixteen of these monkeys showed a positive delayed hypersensitivity response when subsequently skin tested with the immunizing antigen. Ten of the 16 positive reactors survived a P, knowlesi challenge, the remaining 6 showed several indications of protection. None of the 18 control monkeys gave a positive skin reaction or survived the challenging inoculum. Macro- and microscopical evidence suggests that the dermal reaction is of a delayed type. Preliminary biochemical analysis of the antigen used in this experiment is included and its significance is discussed. Hematological data is also presented.

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