Delayed anti-kappa response in kappa-deficient mice after neonatal, oral immunization with kappa-containing IgG

Maternal kappa-containing IgG induces a

Maternal kappa-containing IgG induces a late anti-K response in adult, K-deficient offspring

✍ Otti Bengtsson; Annika Daggfeldt; Kjell-Olov Grönvik; Jan Andersson 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

Kappa ( ‹ )-light (L) chain-deficient (C ‹ -/-) mice readily mount a T cell-dependent antibody response after immunization with ‹ -containing proteins. Such antibody responses are absent in normal (C ‹ +/+) animals because of tolerance due to the abundance of ‹ -L chains expressed on more than 95% o