Delayed and disturbed morphogenesis of the umbilical blood vessels in insulin-like growth factor-II deficient conceptuses (Igf2m+/p−)

✍ Scribed by Amatul Mateen Ahmad; Jason Burns; Richard Gardner; Chris Graham

• Book ID: 102154587
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 133 KB
• Volume: 233
• Category: Article
• ISSN: 1058-8388
• DOI: 10.1002/dvdy.20320

✦ Synopsis

Insulin-like growth factor-II (IGF-II) deficiency occurs when a conceptus inherits an inactive gene from the father (Igf2m؉/p؊): fetal wet weight is reduced to 60% of wild-type, with the decline starting at E11. The umbilical cord vessels of mutant and wild-type were compared. At E8.0 -E8.5, the timing of somite formation and chorioallantoic fusion was not altered. At E14.5-E16.5, the left umbilical artery degenerated approximately 1 day later in Igf2m؉/p؊ conceptuses when compared with the wild-type. In the common umbilical artery at E15.5, muscle volume was reduced by one third in IGF-II deficiency. Treating the umbilical arteries as ideal tubes, the values of radius 4 /length suggest that blood flow through the placenta may be reduced by more than half in the Igf2m؉/p؊ conceptuses.