Delayed allergic reactions following intramuscular L-asparaginase

✍ Scribed by Spiegel, Robert J. ;Echelberger, Candyce K. ;Poplack, David G.

• Book ID: 102520514
• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 216 KB
• Volume: 8
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950080204

✦ Synopsis

Abstract

L‐asparaginase, a highly effective anti‐leukemic enzyme preparation, is now frequently being adminstered intramuscularly in order to decrease the incidence of severe sensitivity reactions. Although the occurrence of immediate hypersensitivity reactions and anaphylaxis has been diminished through this technique, we report three patients who developed delayed allergic reactions occurring hours after drug administration. This suggests that patients receiving L‐asparaginase intramuscularly merit prolonged observation periods beyond the usual one half to one hour.