Delay to institution of therapy and induction of remission using single-drug or combination–disease-modifying antirheumatic drug therapy in early rheumatoid arthritis

✍ Scribed by Timo Möttönen; Pekka Hannonen; Markku Korpela; Martti Nissilä; Hannu Kautiainen; Jorma Ilonen; Leena Laasonen; Oili Kaipiainen-Seppänen; Per Franzen; Tapani Helve; Juhani Koski; Marianne Gripenberg-Gahmberg; Riitta Myllykangas-Luosujärvi; Marjatta Leirisalo-Repo

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 59 KB
• Volume: 46
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.10135

✦ Synopsis

Abstract

Objective

To study the impacts of 1) the delay from the onset of symptoms to the institution of disease‐modifying antirheumatic drug (DMARD) therapy, 2) two treatment strategies (treatment with a combination of DMARDs or with a single drug), and 3) the presence of HLA–DRB1 alleles (shared epitope) on the prediction of disease remission after 2 years in patients with early rheumatoid arthritis (RA).

Methods

In the FIN‐RACo (FINnish Rheumatoid Arthritis Combination therapy) trial, 195 patients with recent‐onset RA (median duration 6 months) were randomly assigned to receive either 1) a combination of DMARDs (sulfasalazine, methotrexate, hydroxychloroquine, and prednisolone) or 2) a single DMARD with or without prednisolone. The presence of a shared epitope was tested for in 165 of the 178 patients completing the study. The additional variables of age, sex, presence of rheumatoid factor, number of fulfilled American College of Rheumatology criteria for the classification of RA, and length of delay from onset of symptoms to institution of therapy were entered into a logistic regression model to determine the significant predictors for remission at 2 years.

Results

The delay to therapy (cut point of 4 months) was the only significant predictor for remission in patients treated using the single‐DMARD strategy, while no variable was a significant predictor for remission in those treated using the combination‐DMARD strategy. The frequency of achieving remission in the combination‐DMARD group after 2 years was similar in patients with short (0–4 months) and long (>4 months) delay periods (11 of 26 patients and 22 of 53 patients, respectively [∼42% in each group]), while the corresponding frequencies in the single‐DMARD group were 8 of 23 patients (35%) and 7 of 63 patients (11%) (P = 0.021). The presence of a shared epitope was not related to the induction of remission.

Conclusion

The delay of a few months from the onset of symptoms to institution of therapy decreases the ability of the traditional single‐drug strategy to induce remission in early RA.