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Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition

✍ Scribed by Marie A. Badalamente; Alfred Stracher

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
246 KB
Volume
23
Category
Article
ISSN
0148-639X

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✦ Synopsis

Inhibition of muscle degeneration by the tripeptide calpain inhibitor, leupeptin, was tested in vivo in a dystrophin-deficient mdx murine model. In a short-term control study, intramuscular administration of leupeptin for 30 days inhibited muscle degeneration as assessed by histologic analysis. Calpain inhibition could be correlated with retention of myofiber size and our results suggest that this may be a promising treatment modality in human Duchenne muscular dystrophy.

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