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Delay of bladder cancer induction in rats treated with N-nitroso-N-butyl-N-(4-hydroxybutyl)amine by administration of sodium-2-mercaptoethanesulfonate (Mesna)

✍ Scribed by Tacchi, Anna M.; Schmähl, Dietrich; Habs, Michael


Book ID
123075859
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
384 KB
Volume
22
Category
Article
ISSN
0304-3835

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The therapeutic effect of an aromatic retinoic acid analogue (Ro 10-9359) and mitomycin C (MMC) on rats with bladder tumours induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was examined. Eight-week-old female Wistar rats were given 0.05% BBN in drinking water for 8 weeks. Therapy was started