𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Delay Model of the Circadian Pacemaker

✍ Scribed by MARTÍN A. LEMA; DIEGO A. GOLOMBEK; JULIÁN ECHAVE

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
176 KB
Volume
204
Category
Article
ISSN
0022-5193

No coin nor oath required. For personal study only.

✦ Synopsis

We present a simple and realistic model of the circadian pacemaker that can be interpreted in molecular terms. The model, which consists of a single time-delay di!erential equation, simulates the expression of a generic clock protein that inhibits its own expression through a feedback mechanism. Despite its simplicity, this model ful"ls most of the necessary characteristics of a realistic representation of natural circadian clocks: robust and stable oscillations with circadian free-running periods, typical phase response curves and entrainment to environmental zeitgebers. The present model reduces the molecular mechanism necessary to sustain stable oscillations to its bare bones, suggesting that the essential factor is the time-delayed negative feedback of the oscillating protein on its own expression.

📜 SIMILAR VOLUMES

Dynamic response of a circadian pacemake
Dynamic response of a circadian pacemaker
✍ Eric L. Peterson 📂 Article 📅 1981 🏛 Springer-Verlag 🌐 English ⚖ 880 KB

The Culex circadian pacemaker's response to phase-resetting light signals was studied in the first 3 cycles of darkness following a 12h light exposure. (1) In both cycles 1 and 2 there is a clear change from "type 1" to "type 0" phase-resetting as the resetting signal is prolonged (Fig. 2). ( 2) Mos

Refinement of Limit Cycle Oscillator Mod
Refinement of Limit Cycle Oscillator Model of the Effects of Light on the Human Circadian Pacemaker
✍ Megan E. Jewett; Richard E. Kronauer 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 258 KB

In 1990, Kronauer proposed a mathematical model of the effects of light on the human circadian pacemaker. Although this model predicted many general features of the response of the human circadian pacemaker to light exposure, additional data now available enable us to refine the original model. We f